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Inside our research, we were being ready to drastically escalate the dose of CX-5461 beyond that realized in the very first-in-human study in sufferers with hematologic cancers. The RP2D of 475 mg/m2 on times 1, eight, and 15 of a four-week cycle, was dependant on phototoxicity, which transpired Regardless of demanding UV gentle avoidance protoco